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KMID : 0351619740150010157
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Kyungpook Medical Journal
1974 Volume.15 No. 1 p.157 ~ p.164
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Changes of the Pulmonary Surfactant Activities Following Carbon Tetrachloride Intoxication in the Rabbit
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徐修之/Suh, Soo Jhi
朱永恩/Choo, Young Eun
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Abstract
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In an attempt to .observe a possible secondary effects of the liver damage on the pulmonary surfactant activities, the intoxication with carbon tetrachloride (CCI~) was induced to the rabbit with ].) the intraperiioneal injec~icn of 1.Oml CCI,/kg BW, and the study was made on 1, 3, 5, and 7 days after the injection, or 2) 0.5m1 CCl~/kg BW was injected intraperitoneally, and the study was made on 1, 2, and 3 `veeks after the injection.
The activities of the pulmonary surfactant were measured by the tension-area diagram of the lung washings recorded by the modified Langmuir-Wilhelmy balance with a synchronized recording system. The protein contents of the lung washings were measured, and the changes of the body weight, and lung wt/body wt ratios were alse studied, and a comparison was made with the control.
The results thus obtained are summarized as follows:
1) The maximal and minimal surface tensions and stability index of the normal rabbit lung washings were 56.1-1-2.5 dynes/cm, 5.51.2 dynes/cm, and 1.70, respectively. The protein contents of the control was 100.1 8.2 ,ug/ml and the lung wt/body wt ratio was (1.100.3) X 10-3.
2) In the group where 1.Oml of CCIa/kg BW was injected, tike pulmonary surfactant activity was decreased from the 1st day of the injection, and the similar te~idency was observed till 7 days after the injection.
When 0.5m1 of CCl.,/kg BW was injected, the surfactant activity did not show any significant change from 1st week till 3rd week comparing with the contro;f.
3) When 1.Oml of CCla/kg BW was injected, the protein contents of the lung washings were generally greater than the control value with the most praminent increase on the 1st day.
In the group where 0.5m1 of CCIa/kg BW `vas injected, the protein contents of the lung washings showed a general tendency of lowered values from the control.
4) The intraperitoneal injection of either 1.Oml or 0.5m1 CCI~/kg BW produced a gradual decrease of the body weights with a concomitant increase of the lung wt/body wt ratios.
5) From the above results, it is postulatel that CCl₂ intoxication produces the decreased activities of the preducton and secretion of the pulmonary surfactant in the typa II alveolar cells.
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